Screening for spinal muscular atrophy (SMA)-Scoping of Work

Scoping work for a decision analytic model and cost effectiveness evaluation of new-born screening for Spinal Muscular Atrophy (SMA).

Therefore, the service is for the provision of a rapid review of the literature and for a plan to prepare for a future modelling study with clinical and cost effectiveness outcomes.

It is not a screening pilot or an evaluation of one.

The purpose of this work is to prepare for a modelling study by: • Objective 1: Conducting a review of available decision analytic modelling studies and cost effectiveness evaluations which address new-born screening for SMA in the era of novel treatments • Objective 2: Developing an evidence map of published studies and evaluations of PCR based screening and treatment in presymptomatic SMA • Objective 3: Proposing a plan for a modelling study with clinical and cost effectiveness outcomes Contract term: 12 months with the option to extend for a period or periods of up to further 18 months Estimated contract value (including extensions): £90,000 excluding VAT (£108,000 including VAT) The opportunity will be available on the DHSC Atamis eTendering System.

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