Onasemnogene Abeparvovec Intravenous (Zolgensma®) Service & Onasemnogene Abeparvovec Intrathecal (OAV101 IT) Service
The submission route named on the official notice.
This is a large award for Health & Social Care — above three-quarters of comparable contracts. Based on 32,734 valued Health & Social Care tenders in our corpus.
Onasemnogene abeparvovec intravenous (Zolgensma®) is a one-time, in vivo gene replacement therapy, for use in babies aged 12 months and under, that utilises an adeno-associated virus serotype 9 (AAV9) vector, modified to contain a functional copy of the human SMN1 gene.
It is administered intravenously, allowing the vector to deliver the gene into motor neurones and peripheral tissues, enabling the sustained expression of survival motor neuron (SMN) protein, which is deficient or mutated in individuals with SMA.<br/><br/>Onasemnogene abeparvovec intrathecal (OAV101 IT) is a one-time in vivo gene replacement therapy for patients with SMA, proposed to treat individuals with SMA aged 2 years and over.
This intrathecal injection will be used to treat a distinct cohort of SMA patients to Zolgensma.
It will be assessed via NICE’s technology appraisal programme, with an expected final guidance publication date in late 2026.
What the supplier must deliver
It is administered intravenously, allowing the vector
It is administered intravenously, allowing the vector to deliver the gene into motor neurones and peripheral tissues, enabling the sustained expression of survival motor neuron (SMN) protein, which is deficient or mutated in individuals with SMA.
Derived from the notice text — always confirm against the original documents.
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- OCID
- ocds-h6vhtk-06ae08
- Stage
- tender · Open
- Source
- Find a Tender
- Buyer ref
- 053026-2026
Contains public sector information licensed under the Open Government Licence v3.0. Source data © Crown copyright.
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